Vesselina Kasarova was born in Stara Zagora (Bulgaria) and started playing the piano at the age of four. After completing her concert diploma, she studied singing with Ressa Koleva at the Sofia Music Academy and performed major roles at the national opera there as a student.
After completing her studies in 1989, a two-year permanent contract led her to the Zürich Opera House, where she quickly became a crowd favourite and was hailed as a great discovery by international experts. In the same year, she also won first prize at the German singing competition “New Voices” in Gütersloh.
In the Mozart year 1991, Vesselina Kasarova made her debut at the Salzburg Festival with two matinées in the Mozarteum (Betulia liberata KV 118) and as Annio in the revival of La Clemenza di Tito, directed by Sir Colin Davis. Other roles at the Salzburg Festival were Tancredi, Ombra felice, Zerlina, Farnace, Sesto and Marguerite (La damnation de Faust). In the autumn of the same year, Vesselina Kasarova gave her highly acclaimed debut at the Vienna State Opera as Rosina (Il barbiere di Siviglia) under Donald Runnicles.
With roles by Mozart (Cherubino, Idamante, Sesto, Dorabella) and Rossini (Rosina, Tancredi, Isabella, Angelina) as well as Romeo (I Capuleti ei Montecchi), Giovanna Seymour (Anna Bolena), Charlotte (Werther) and others, she also appeared at Le Grand Théâtre de Genève, Royal Opera House Covent Garden, Teatre del Liceu in Barcelona, Zürich Opera House, Deutsche Oper Berlin, Bavarian State Opera Munich, Opéra National de Paris (Bastille, Garnier), Lyric Opera of Chicago, San Francisco Opera, Vienna State Opera in Amsterdam as well as at the Maggio Musicale Fiorentino and Rossini Opera Festival in Pesaro and worked with conductors such as Nikolaus Harnoncourt, Sir Colin Davis, Pinchas Steinberg, Donald Runnicles, Seji Ozawa, Semyon Bychkov, Daniel Barenboim, Riccardo Muti, Marcello Viotti, Alberto Zedda, Franz Welser-Möst, Sir Roger Norrington, Eve Queler, Wolfgang Sawallisch, Ivor Bolton and Friedrich Haider.
Recitals and concerts have taken Vesselina Kasarova to Munich, Berlin, Rome, Paris, Vienna, Dresden, the Scala in Milan, Wigmore Hall London, Carnegie Hall New York, Schubertiade Feldkirch and the Festival de la Musique Montreux-Vevey.
Vesselina Kasarova has recorded numerous CDs for RCA Red Seal, which have received multiple awards.
She has been a Swiss citizen since 1997 and lives in Zürich.